A potential anti-coagulant role of complement factor H.
Mol Immunol
; 59(2): 188-93, 2014 Jun.
Article
en En
| MEDLINE
| ID: mdl-24632373
ABSTRACT
Anti-phospholipid syndrome (APS) is a complex autoimmune disease, associated with recurrent venous and arterial thrombosis in various tissues. APS is associated with specific antibodies against plasma beta-2 glycoprotein 1 (ß2-GP1), and these antibodies react with ß2-GP1 bound to negatively charged phospholipids (e.g. cardiolipin) on cell membranes. Some APS patients also have autoantibodies to complement factor H (FH), a homologue of ß2-GP1, which also binds to anionic phospholipids. ß2-GP1 has earlier been shown to inhibit the intrinsic (contact) activated blood coagulation pathway, promoted by anionic phospholipids. Here we examine whether FH could have similar anti-thrombotic properties. In vitro experiments with surface-bound phospholipids and human plasma, in the presence of FH, confirm this hitherto unreported property of FH.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Coagulación Sanguínea
/
Anticuerpos Antifosfolípidos
/
Beta 2 Glicoproteína I
Límite:
Humans
Idioma:
En
Revista:
Mol Immunol
Año:
2014
Tipo del documento:
Article
País de afiliación:
Reino Unido