GABA actions and ionic plasticity in epilepsy.
Curr Opin Neurobiol
; 26: 34-41, 2014 Jun.
Article
en En
| MEDLINE
| ID: mdl-24650502
ABSTRACT
Concepts of epilepsy, based on a simple change in neuronal excitation/inhibition balance, have subsided in face of recent insights into the large diversity and context-dependence of signaling mechanisms at the molecular, cellular and neuronal network level. GABAergic transmission exerts both seizure-suppressing and seizure-promoting actions. These two roles are prone to short-term and long-term alterations, evident both during epileptogenesis and during individual epileptiform events. The driving force of GABAergic currents is controlled by ion-regulatory molecules such as the neuronal K-Cl cotransporter KCC2 and cytosolic carbonic anhydrases. Accumulating evidence suggests that neuronal ion regulation is highly plastic, thereby contributing to the multiple roles ascribed to GABAergic signaling during epileptogenesis and epilepsy.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
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Simportadores
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Epilepsia
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Ácido gamma-Aminobutírico
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Red Nerviosa
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Plasticidad Neuronal
Límite:
Animals
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Humans
Idioma:
En
Revista:
Curr Opin Neurobiol
Asunto de la revista:
BIOLOGIA
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NEUROLOGIA
Año:
2014
Tipo del documento:
Article