The use of N-(2-mercaptopropionyl)-glycine (MPG) for preparation and storage of platelets.
Folia Haematol Int Mag Klin Morphol Blutforsch
; 115(4): 455-9, 1988.
Article
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| MEDLINE
| ID: mdl-2465952
ABSTRACT
The SH group containing drug MPG which inhibits platelet aggregation in a reversible manner was used as a cytoprotective substance in some experiments on preparation and storage of human platelets for transfusion. In vitro (n = 6) concentration, morphology score, HSR and aggregation of stored platelets were measured after simulating in vitro the post transfusional conditions by resuspension of stored platelets in fresh drawn plasma (pH 7.4, 37 degrees C). In vivo (n = 2) Autologous platelets stored for 48 h at 22 degrees C were labelled with 111In and retransfused. The results obtained from platelets prepared and stored in plasma containing MPG were compared with those obtained from control platelets without MPG.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plaquetas
/
Conservación de la Sangre
/
Tiopronina
Límite:
Humans
Idioma:
En
Revista:
Folia Haematol Int Mag Klin Morphol Blutforsch
Año:
1988
Tipo del documento:
Article