Contrast enhancement using silica microspheres in coherent anti-Stokes Raman spectroscopic imaging.
Opt Express
; 22(3): 2889-96, 2014 Feb 10.
Article
en En
| MEDLINE
| ID: mdl-24663581
ABSTRACT
Coherent anti-Stokes Raman scattering (CARS) microscopy is a powerful imaging technique that can provide chemical information of organic and nonorganic materials through vibrational spectroscopy. However, its contrast is not sufficient for monitoring thin film materials. In this study, silica microspheres were employed for enhancing the signal contrast in CARS imaging. One layer of optically transparent silica microspheres was self-assembled onto polymer grating samples to enhance the CARS signals. The highest contrast enhancement factor of 12.5 was achieved using 6.1-µm-diameter microspheres. Finite-difference time-domain method (FDTD) simulation was conducted to simulate the contrast enhancement with silica microspheres of different diameters.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Espectrometría Raman
/
Algoritmos
/
Aumento de la Imagen
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Dióxido de Silicio
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Imagen Molecular
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Modelos Químicos
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Opt Express
Asunto de la revista:
OFTALMOLOGIA
Año:
2014
Tipo del documento:
Article