In vivo function of the ER-Golgi transport protein LMAN1 in photoreceptor homeostasis.
Adv Exp Med Biol
; 801: 395-9, 2014.
Article
en En
| MEDLINE
| ID: mdl-24664723
ABSTRACT
LMAN1 is a type I transmembrane protein that selectively transports its cargo proteins from ER to ER-Golgi intermediate compartment (ERGIC) and Golgi. Lman1 is a direct target of the transcription factor NRL in mouse retina. Therefore, we examined the in vivo function of LMAN1 in retina. Although Lman1 (- / -) mouse eyes did not show abnormality in histology and electroretinogram analysis at 3 months, Lman1 (- / -) retina at 6 months showed a decrease in cis-Golgi markers GM130 and GRASP65. We also observed abnormal level and location of Rhodopsin in these mice. Taken together, LMAN1 may play a role in photoreceptor gene transport and homeostasis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Fotorreceptoras de Vertebrados
/
Lectinas de Unión a Manosa
/
Retículo Endoplásmico
/
Aparato de Golgi
/
Homeostasis
/
Proteínas de la Membrana
Límite:
Animals
Idioma:
En
Revista:
Adv Exp Med Biol
Año:
2014
Tipo del documento:
Article