[Dynamic monitoring on ovarian function among patients having had cervical squamous cell carcinoma transposition surgery].

ABSTRACT

UNLABELLED To investigate the changes in ovarian function and the radiotherapeutic influence on ovarian function on patients with cervical squamous cell carcinoma. METHODS: We retrospectively analyzed 53 cases of cervical cancer patients FIGO staging I B1- II B who had received ovarian transposition surgery at the Maternal and Child Health Hospital of Jiangxi province from January 2009 to June 2012. All the patients included in the study were FIGO staging I B1- II B and had undergone radiation therapy, including 38 staging I B1- II A2 cervical cancer patients receiving chemo-therapy after radical radiotherapy due to the presence of risk factors and other 15 patients with stage II B to radical concurrent chemoradiotherapy ovarian transposition. Ovarian transposition methods would include laparoscopic ovarian transposition and transabdominal ovarian transposition. 15 concurrent patients with stage II B who currently receiving chemo-radiotherapy were under laparoscopic ovarian transposition. Among the 38 radical hysterectomy patients, 31 were having abdominal ovarian transposition, and the remaining 7 cases were laparoscopic. All the 53 patients had undergone radiotherapy. The levels of serum female hormones FSH, LH, E2 were determined to monitor the ovarian endocrine function. RESULTS: According to FIGO staging, 18 cases were stage I B1, 15 cases I B2, 3 cases II A1, 2 cases II A2 and 15 cases II B. Patients' age range was from 28 to 44 years old, with an average of 37.7 years, median age as 38 years. 14 patients (63.6%) were still normal ovarian function after radiotherapy by laparoscopic ovarian transposition, which was 100.0% before radiotherapy. There was a significant difference (P < 0.05)compared with before radiotherapy. After transabdominal ovarian transposition surgery and radiotherapy, normal ovarian function 22 cases (71.0%), and there was a significant difference (P < 0.05) compared with before radiotherapy. No significant difference was found with regard to the proportion of normal ovarian function after radiotherapy between the two groups of patients with laparoscopic and transabdominal ovarian transposition (P > 0.05). CONCLUSION: For the young cervical cancer patients, even with ovarian transposition, ovarian dysfunction was still evident after radiotherapy. There was no significant difference between laparoscopic and transabdominal ovarian transposition.