[End-stage renal disease after sarcoma therapy - case 3/2014]. / Terminales Nierenversagen nach Sarkomtherapie - Fall 3/2014.
Dtsch Med Wochenschr
; 139(15): 785, 2014 Apr.
Article
en De
| MEDLINE
| ID: mdl-24691693
ABSTRACT
HISTORY AND ADMISSION FINDINGS:
A 67-year-old male patient developed progressive renal failure following successful treatment of a soft tissue sarcoma that comprised surgical resection after neoadjuvant radiochemotherapy with the application of doxorubicin (cumulative dose 180 mg/m²) and ifosfamide (cumulative dose 33 g/m²). INVESTIGATIONS Plasma creatinine concentration was elevated to 4.5 mg/dl. Upon detection of glucosuria and α1-microglobulinuria renal biopsy was performed. DIAGNOSIS, TREATMENT AND COURSE Histologic analysis revealed massively injured tubules that could be explained by a toxic effect of ifosfamide. Glomeruli were not affected and appeared normal. After two months of conservative therapy, the patient developed an uremic syndrome requiring hemodialysis. Ever since kidney function did not recover albeit preserved diuresis.CONCLUSIONS:
Ifosfamide can cause end-stage renal disease by a tubulotoxic effect that may be the result of a selective intracellular uptake into the proximal tubule via the human organic cation transporter 2 (OCT2).
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sarcoma
/
Neoplasias de los Tejidos Blandos
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Fallo Renal Crónico
Tipo de estudio:
Diagnostic_studies
Límite:
Aged
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Humans
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Male
Idioma:
De
Revista:
Dtsch Med Wochenschr
Año:
2014
Tipo del documento:
Article