Codon sextets with leading role of serine create "ideal" symmetry classification scheme of the genetic code.
Gene
; 543(1): 45-52, 2014 Jun 10.
Article
en En
| MEDLINE
| ID: mdl-24709107
ABSTRACT
The standard classification scheme of the genetic code is organized for alphabetic ordering of nucleotides. Here we introduce the new, "ideal" classification scheme in compact form, for the first time generated by codon sextets encoding Ser, Arg and Leu amino acids. The new scheme creates the known purine/pyrimidine, codon-anticodon, and amino/keto type symmetries and a novel A+U rich/C+G rich symmetry. This scheme is built from "leading" and "nonleading" groups of 32 codons each. In the ensuing 4 × 16 scheme, based on trinucleotide quadruplets, Ser has a central role as initial generator. Six codons encoding Ser and six encoding Arg extend continuously along a linear array in the "leading" group, and together with four of six Leu codons uniquely define construction of the "leading" group. The remaining two Leu codons enable construction of the "nonleading" group. The "ideal" genetic code suggests the evolution of genetic code with serine as an initiator.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Codón
/
Código Genético
/
Aminoácidos
/
Conformación de Ácido Nucleico
Idioma:
En
Revista:
Gene
Año:
2014
Tipo del documento:
Article
País de afiliación:
Croacia