Conformation sequence recovery of a non-periodic object from a diffraction-before-destruction experiment.
Opt Express
; 22(7): 8085-93, 2014 Apr 07.
Article
en En
| MEDLINE
| ID: mdl-24718184
ABSTRACT
Knowledge of the sequence of different conformational states of a protein molecule is key to better understanding its biological function. A diffraction pattern from a single conformational state can be captured with an ultrafast X-ray Free-Electron Laser (XFEL) before the target is completely annihilated by the radiation. In this paper, we report the first experimental demonstration of conformation sequence recovery using diffraction patterns from randomly ordered conformations of a non-periodic object using the dimensional reduction technique Isomap and coherent diffraction imaging.
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01-internacional
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MEDLINE
Idioma:
En
Revista:
Opt Express
Asunto de la revista:
OFTALMOLOGIA
Año:
2014
Tipo del documento:
Article