Polyacrylamide-based biocompatible Nanoplatform enhances the tumor uptake, PET/fluorescence imaging and anticancer activity of a chlorophyll analog.
Theranostics
; 4(6): 614-28, 2014.
Article
en En
| MEDLINE
| ID: mdl-24723983
ABSTRACT
In this report we demonstrate the outstanding advantages of multifunctional nanoplatforms for cancer-imaging and therapy. The non-toxic polyacrylamide (PAA) nanoparticles (size18-25 nm) formulation drastically changed the pharmacokinetic profile of the ¹²4I- labeled chlorophyll-a derivative (formulated in 10% ethanol in PBS) with a remarkable enhancement in tumor uptake, and significantly reduced uptake in spleen and liver. Among the various nanoformulations investigated, the ¹²4I- labeled photosensitizer (dose 0.6142 MBq), and the cyanine dye-nanoparticles (CD-NP) conjugate (dose 0.3 µmol/kg) in combination showed great potential for tumor imaging (PET/NIR fluorescence) in BALB/c mice bearing Colon26 tumors. Compared to free non-labeled photosensitizer, the corresponding PAA nanoformulation under similar treatment parameters showed a remarkable enhancement in long-term tumor cure by PDT (photodynamic therapy) and provides an opportunity to develop a single nanoplatform for tumor-imaging (PET/fluorescence) and phototherapy, a practical "See and Treat" approach.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fotoquimioterapia
/
Clorofila
/
Fármacos Fotosensibilizantes
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Neoplasias del Colon
/
Tomografía de Emisión de Positrones
/
Nanopartículas
Límite:
Animals
Idioma:
En
Revista:
Theranostics
Año:
2014
Tipo del documento:
Article
Pais de publicación:
AU
/
AUSTRALIA
/
AUSTRÁLIA