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Ultrafast Structural Dynamics of BlsA, a Photoreceptor from the Pathogenic Bacterium Acinetobacter baumannii.
Brust, Richard; Haigney, Allison; Lukacs, Andras; Gil, Agnieszka; Hossain, Shahrier; Addison, Kiri; Lai, Cheng-Tsung; Towrie, Michael; Greetham, Gregory M; Clark, Ian P; Illarionov, Boris; Bacher, Adelbert; Kim, Ryu-Ryun; Fischer, Markus; Simmerling, Carlos; Meech, Stephen R; Tonge, Peter J.
Afiliación
  • Brust R; Department of Chemistry, Stony Brook University , Stony Brook, New York 11794-3400, United States.
  • Haigney A; Department of Chemistry, Stony Brook University , Stony Brook, New York 11794-3400, United States.
  • Lukacs A; School of Chemistry, University of East Anglia , Norwich Research Park, Norwich NR4 7TJ, United Kingdom ; Department of Biophysics, Medical School, University of Pecs , Pecs, Hungary.
  • Gil A; Department of Chemistry, Stony Brook University , Stony Brook, New York 11794-3400, United States.
  • Hossain S; Department of Chemistry, Stony Brook University , Stony Brook, New York 11794-3400, United States.
  • Addison K; School of Chemistry, University of East Anglia , Norwich Research Park, Norwich NR4 7TJ, United Kingdom.
  • Lai CT; Department of Chemistry, Stony Brook University , Stony Brook, New York 11794-3400, United States.
  • Towrie M; Central Laser Facility, Research Complex at Harwell , Harwell Science and Innovation Campus, Didcot, Oxon OX11 0QX, United Kingdom.
  • Greetham GM; Central Laser Facility, Research Complex at Harwell , Harwell Science and Innovation Campus, Didcot, Oxon OX11 0QX, United Kingdom.
  • Clark IP; Central Laser Facility, Research Complex at Harwell , Harwell Science and Innovation Campus, Didcot, Oxon OX11 0QX, United Kingdom.
  • Illarionov B; Institut für Biochemie und Lebensmittelchemie, Universität Hamburg , Grindelallee 117, D-20146 Hamburg, Germany.
  • Bacher A; Institut für Biochemie und Lebensmittelchemie, Universität Hamburg , Grindelallee 117, D-20146 Hamburg, Germany.
  • Kim RR; Institut für Biochemie und Lebensmittelchemie, Universität Hamburg , Grindelallee 117, D-20146 Hamburg, Germany.
  • Fischer M; Institut für Biochemie und Lebensmittelchemie, Universität Hamburg , Grindelallee 117, D-20146 Hamburg, Germany.
  • Simmerling C; Department of Chemistry, Stony Brook University , Stony Brook, New York 11794-3400, United States.
  • Meech SR; School of Chemistry, University of East Anglia , Norwich Research Park, Norwich NR4 7TJ, United Kingdom.
  • Tonge PJ; Department of Chemistry, Stony Brook University , Stony Brook, New York 11794-3400, United States.
J Phys Chem Lett ; 5(1): 220-224, 2014 Jan 02.
Article en En | MEDLINE | ID: mdl-24723998
ABSTRACT
Acinetobacter baumannii is an important human pathogen that can form biofilms and persist under harsh environmental conditions. Biofilm formation and virulence are modulated by blue light, which is thought to be regulated by a BLUF protein, BlsA. To understand the molecular mechanism of light sensing, we have used steady-state and ultrafast vibrational spectroscopy to compare the photoactivation mechanism of BlsA to the BLUF photosensor AppA from Rhodobacter sphaeroides. Although similar photocycles are observed, vibrational data together with homology modeling identify significant differences in the ß5 strand in BlsA caused by photoactivation, which are proposed to be directly linked to downstream signaling.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Phys Chem Lett Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Phys Chem Lett Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos