Phospholipid micelle encapsulated gadolinium oxide nanoparticles for imaging and gene delivery.
RSC Adv
; 3(8): 2727-2735, 2013 Feb 28.
Article
en En
| MEDLINE
| ID: mdl-24724012
ABSTRACT
We encapsulated gadolinium oxide (Gd2O3) nanoparticles within phospholipid micelles as a novel low cytotoxic T1-weighted MRI imaging contrast agent (MGdNPs) that can also deliver small molecules such as DNA plasmids. MGdNPs show relatively good MRI relaxivity values, negligible cytotoxicity, excellent cellular uptake and expression of DNA plasmids in vivo. Biodistribution studies in mice show that intranasal and intraperitoneal administration of MGdNPs can effectively target specific organs.
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Colección:
01-internacional
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MEDLINE
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En
Revista:
RSC Adv
Año:
2013
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Article