Triazole-linked analogues of DNA and RNA ((TL)DNA and (TL)RNA): synthesis and functions.
Chem Rec
; 14(1): 41-51, 2014 Feb.
Article
en En
| MEDLINE
| ID: mdl-24734308
ABSTRACT
Click chemistry has provided us with access to DNA and RNA analogues with non-natural triazole internucleoside linkages. The bond periodicity of the oligonucleotides was designed to enforce duplex formation with natural congeners, and the non-cleavable linkages protect the oligomers against nuclease digestion. This account reviews the progress of the triazole-linked analogues over the past five years. Reinforced by their synthetic robustness, these analogues may find various utilities as tools for exploratory research.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Triazoles
/
ADN
/
ARN
Idioma:
En
Revista:
Chem Rec
Asunto de la revista:
QUIMICA
Año:
2014
Tipo del documento:
Article