Molecular biodiversity and recent analytical developments: a marriage of convenience.
Biotechnol Adv
; 32(6): 1102-10, 2014 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-24780152
ABSTRACT
Nature has developed an outstanding bio- and molecular diversity as a result of billion years of evolution resulting in a tremendous number of secondary metabolites. Among them a small part has been so far explored for discovery of lead compounds. The lead discovery from natural sources is a technological challenge for the pharmaceutical industry. The bio- and molecular diversity in plants, animals and microorganisms, as sources for new leads, and the remarkable recent developments in NMR, mass spectrometry coupled with advanced separation techniques (LC and GC), high throughput screening, and structure-based virtual screening are discussed in this article.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Biotecnología
/
Estructura Molecular
/
Biodiversidad
/
Descubrimiento de Drogas
Límite:
Animals
Idioma:
En
Revista:
Biotechnol Adv
Año:
2014
Tipo del documento:
Article