Effects of Jitai tablet, a traditional Chinese medicine, on plasma adrenocorticotropic hormone and cortisol levels in heroin addicts during abstinence.
J Altern Complement Med
; 20(7): 527-34, 2014 Jul.
Article
en En
| MEDLINE
| ID: mdl-24786196
ABSTRACT
OBJECTIVES:
To investigate the changes in adrenocorticotropic hormone (ACTH) and cortisol in heroin addicts given Jitai tablet treatment during abstinence.DESIGN:
Double-blind, randomized, placebo-controlled clinical trial. SETTINGS/LOCATION Drug Rehabilitation Bureau of Shanghai Police, China.PARTICIPANTS:
99 volunteers, including 69 heroin addicts and 30 healthy volunteers.INTERVENTIONS:
69 heroin addicts randomly divided into two groups the Jitai tablet group, which comprised 34 heroin addicts given Jitai tablet treatment during abstinence, and the placebo group, which comprised 35 heroin addicts given placebo. A control group consisted of 30 sex- and age-matched healthy volunteers. OUTCOMEMEASURES:
ACTH and cortisol in plasma were measured in all groups at baseline and in the Jitai tablet and placebo groups on the third, seventh, and 14th days of abstinence.RESULTS:
Levels of both ACTH (p<.01) and cortisol (p<.001) were significantly higher in heroin addicts at baseline than in the healthy volunteers. Jitai tablet treatment restored plasma cortisol levels to normal more rapidly than did placebo treatment (p<.05), but not ACTH levels. A positive correlation between ACTH and cortisol values at baseline (p<.01) was also found with withdrawal symptom scores and daily dosages of heroin.CONCLUSIONS:
Heroin addicts could respond to Jitai tablets through changes in the hypothalamus-pituitary-adrenal axis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndrome de Abstinencia a Sustancias
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Hidrocortisona
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Medicamentos Herbarios Chinos
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Hormona Adrenocorticotrópica
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Dependencia de Heroína
Tipo de estudio:
Clinical_trials
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
J Altern Complement Med
Asunto de la revista:
TERAPIAS COMPLEMENTARES
Año:
2014
Tipo del documento:
Article
País de afiliación:
China