Expression of tumor necrosis factor α and its correlation with severity of oral submucous fibrosis: a case-control study.
Oral Surg Oral Med Oral Pathol Oral Radiol
; 117(6): 704-8, 2014 Jun.
Article
en En
| MEDLINE
| ID: mdl-24787450
ABSTRACT
OBJECTIVE:
The objective of this case-control study was to evaluate the plasma tumor necrosis factor α (TNF-α) levels in patients with oral submucous fibrosis and to determine the relation of plasma TNF-α levels with the severity of oral submucous fibrosis. STUDYDESIGN:
Blood samples were collected from 25 patients who were diagnosed with oral submucous fibrosis and from 25 age- and sex-matched control participants. The plasma was isolated by centrifugation of blood samples. The levels of plasma TNF-α were estimated using enzyme-linked immunosorbent assay.RESULTS:
A total of 19 out of 25 patients had detectable plasma TNF-α levels ranging from 0.1 to 106.4 pg/mL (mean, 23.46 pg/mL), whereas only 12 out of 25 control participants had detectable plasma TNF-α levels ranging from 0.1 to 33.3 pg/mL (mean, 6.93 pg/mL). The difference between the TNF-α levels of patients and controls was statistically significant (P = .015) according to the Mann-Whitney test.CONCLUSIONS:
Patients with oral submucous fibrosis had significantly increased TNF-α levels compared with controls.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fibrosis de la Submucosa Bucal
/
Factor de Necrosis Tumoral alfa
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Oral Surg Oral Med Oral Pathol Oral Radiol
Año:
2014
Tipo del documento:
Article
País de afiliación:
India