Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis.

De Vita, Serena; Schneider, Rebekka K; Garcia, Michael; Wood, Jenna; Gavillet, Mathilde; Ebert, Benjamin L; Gerbaulet, Alexander; Roers, Axel; Levine, Ross L; Mullally, Ann; Williams, David A

De Vita, Serena; Schneider, Rebekka K; Garcia, Michael; Wood, Jenna; Gavillet, Mathilde; Ebert, Benjamin L; Gerbaulet, Alexander; Roers, Axel; Levine, Ross L; Mullally, Ann; Williams, David A.

Afiliación

De Vita S; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Schneider RK; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Garcia M; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Wood J; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Gavillet M; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Ebert BL; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Gerbaulet A; Institute for Immunology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.
Roers A; Institute for Immunology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.
Levine RL; Human Oncology and Pathogenesis Program, and Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.
Mullally A; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Williams DA; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

PLoS One ; 9(5): e96209, 2014.

Article en En | MEDLINE | ID: mdl-24788138

Asunto(s)

Proteínas de Unión al ADN/metabolismo; Mastocitosis Sistémica/metabolismo; Proteínas Proto-Oncogénicas c-kit/metabolismo; Proteínas Proto-Oncogénicas/metabolismo; Animales; Azacitidina/análogos & derivados; Azacitidina/uso terapéutico; Western Blotting; Células de la Médula Ósea/metabolismo; Células de la Médula Ósea/patología; Línea Celular Tumoral; Proliferación Celular/genética; Células Cultivadas; Proteínas de Unión al ADN/genética; Dasatinib; Decitabina; Dioxigenasas; Modelos Animales de Enfermedad; Quimioterapia Combinada; Inhibidores Enzimáticos/uso terapéutico; Esófago/metabolismo; Esófago/patología; Mucosa Gástrica/metabolismo; Humanos; Mastocitos/metabolismo; Mastocitos/patología; Mastocitosis Sistémica/tratamiento farmacológico; Mastocitosis Sistémica/genética; Ratones Noqueados; Ratones Transgénicos; Mutación Missense; Leucemia-Linfoma Linfoblástico de Células Precursoras/genética; Leucemia-Linfoma Linfoblástico de Células Precursoras/metabolismo; Proteínas Proto-Oncogénicas/genética; Proteínas Proto-Oncogénicas c-kit/genética; Pirimidinas/uso terapéutico; Interferencia de ARN; Piel/metabolismo; Piel/patología; Estómago/patología; Tiazoles/uso terapéutico

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas / Proteínas Proto-Oncogénicas c-kit / Mastocitosis Sistémica / Proteínas de Unión al ADN Tipo de estudio: Prognostic_studies Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos

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