Lipin 2 binds phosphatidic acid by the electrostatic hydrogen bond switch mechanism independent of phosphorylation.

Eaton, James M; Takkellapati, Sankeerth; Lawrence, Robert T; McQueeney, Kelley E; Boroda, Salome; Mullins, Garrett R; Sherwood, Samantha G; Finck, Brian N; Villén, Judit; Harris, Thurl E

Eaton, James M; Takkellapati, Sankeerth; Lawrence, Robert T; McQueeney, Kelley E; Boroda, Salome; Mullins, Garrett R; Sherwood, Samantha G; Finck, Brian N; Villén, Judit; Harris, Thurl E.

Afiliación

Eaton JM; From the Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908.
Takkellapati S; From the Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908.
Lawrence RT; the Department of Genome Sciences, University of Washington, Seattle, Washington 98105.
McQueeney KE; From the Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908.
Boroda S; From the Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908.
Mullins GR; From the Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908.
Sherwood SG; From the Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908.
Finck BN; the Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, and.
Villén J; the Department of Genome Sciences, University of Washington, Seattle, Washington 98105.
Harris TE; From the Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, teh3c@virginia.edu.

J Biol Chem ; 289(26): 18055-66, 2014 Jun 27.

Article en En | MEDLINE | ID: mdl-24811178

Asunto(s)

Fosfatidato Fosfatasa/química; Fosfatidato Fosfatasa/metabolismo; Ácidos Fosfatidicos/metabolismo; Secuencias de Aminoácidos; Animales; Humanos; Enlace de Hidrógeno; Insulina/metabolismo; Cinética; Ratones; Fosfatidato Fosfatasa/genética; Fosforilación; Unión Proteica; Transducción de Señal; Electricidad Estática

Palabras clave

Diacylglycerol; Enzyme Kinetics; Lipin 2; Phosphatidic Acid; Phosphatidic Acid Phosphatase; Phosphatidylethanolamine; Phosphorylation; Polybasic Domain; lpin2; mTOR

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Fosfatidicos / Fosfatidato Fosfatasa Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos

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