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Drug delivery: beyond active tumour targeting.
Sagnella, Sharon M; McCarroll, Joshua A; Kavallaris, Maria.
Afiliación
  • Sagnella SM; Australian Centre for Nanomedicine, University of New South Wales, Sydney, Australia; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, Australia.
  • McCarroll JA; Australian Centre for Nanomedicine, University of New South Wales, Sydney, Australia; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, Australia.
  • Kavallaris M; Australian Centre for Nanomedicine, University of New South Wales, Sydney, Australia; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, Australia. Electronic address: m.kavallaris@ccia.unsw.edu.au.
Nanomedicine ; 10(6): 1131-7, 2014 Aug.
Article en En | MEDLINE | ID: mdl-24823644
Despite improvements in our understanding of cancer and the concept of personalised medicine, cancer is still a major cause of death. It is established that solid tumours are highly heterogeneous, with a complex tumour microenvironment. Indeed, the tumour microenvironment is made up of a collection of immune cells, cancer-activated fibroblasts, and endothelial cells and in some cases a dense extracellular matrix. Accumulating evidence shows that the tumour microenvironment is a major barrier for the effective delivery of therapeutic drugs to tumour cells. Importantly, nanotechnology has come to the forefront as highly effective delivery vehicles for therapeutic agents. This perspective will discuss how nanomedicine can be used to target and deliver therapeutic drugs specifically to tumour cells. Moreover, emerging opportunities to modulate the tumour microenvironment and increase the delivery and efficacy of chemotherapy agents to solid tumours will be highlighted. FROM THE CLINICAL EDITOR: Improving drug delivery to treatment resistant tumors is a major target of many nanomedicine-based applications. This comprehensive review discusses the currently available and emerging opportunities, in addition to discussing tumor microenvironment modulation to facilitate efficient delivery.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Neoplasias / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Nanomedicine Asunto de la revista: BIOTECNOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Neoplasias / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Nanomedicine Asunto de la revista: BIOTECNOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos