Gombaspiroketals A-C, sesterterpenes from the sponge Clathria gombawuiensis.
Org Lett
; 16(11): 2826-9, 2014 Jun 06.
Article
en En
| MEDLINE
| ID: mdl-24824092
ABSTRACT
Gombaspiroketals A-C (1-3), tetracyclic sesterterpenes of a novel skeletal class, were isolated from the Korean marine sponge Clathria gombawuiensis. On the basis of the combined spectroscopic analyses, the structures of these compounds were determined to be highly rearranged sesterterpene spiroketal methoxyacetals (1 and 2) and a corresponding hemiacetal (3). The relative and absolute configurations were assigned by NOESY analysis and ECD calculations, respectively. These compounds exhibited moderate cytotoxicities and antibacterial activities.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Poríferos
/
Sesquiterpenos
/
Compuestos de Espiro
/
Sesterterpenos
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Furanos
/
Antibacterianos
/
Antineoplásicos
Límite:
Animals
País/Región como asunto:
Asia
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2014
Tipo del documento:
Article
Pais de publicación:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA