Ultrastructural pathology of anaplastic and grade II ependymomas reveals distinctive ciliary structures--electron microscopy redux.
Ultrastruct Pathol
; 39(1): 23-9, 2015 Feb.
Article
en En
| MEDLINE
| ID: mdl-24830503
ABSTRACT
Ependymoma tumors likely derive from the ependymal cells lining the CNS ventricular system. In grade II ependymomas, tumor cells resemble typical ependymocytes, while anaplastic ependymomas are poorly differentiated. We studied three grade II and one anaplastic ependymoma, focusing on the ciliary structures. To unambiguously characterize the ultrastructure and number of cilia, we performed electron microscopy serial section analysis of individual cells. Differentiated ependymomas contained large basal bodies and up to three cilia, and lacked centrioles. Anaplastic ependymoma cells showed instead two perpendicularly oriented centrioles and lacked cilia or basal bodies. These findings could contribute to understand the mechanisms of ependymoma aggressiveness.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Encefálicas
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Cilios
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Ependimoma
Límite:
Adult
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Ultrastruct Pathol
Año:
2015
Tipo del documento:
Article
País de afiliación:
España