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Non-coding RNAs and gastric cancer.
Li, Pei-Fei; Chen, Sheng-Can; Xia, Tian; Jiang, Xiao-Ming; Shao, Yong-Fu; Xiao, Bing-Xiu; Guo, Jun-Ming.
Afiliación
  • Li PF; Pei-Fei Li, Sheng-Can Chen, Tian Xia, Xiao-Ming Jiang, Yong-Fu Shao, Bing-Xiu Xiao, Jun-Ming Guo, Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, Zhejiang Province, China.
  • Chen SC; Pei-Fei Li, Sheng-Can Chen, Tian Xia, Xiao-Ming Jiang, Yong-Fu Shao, Bing-Xiu Xiao, Jun-Ming Guo, Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, Zhejiang Province, China.
  • Xia T; Pei-Fei Li, Sheng-Can Chen, Tian Xia, Xiao-Ming Jiang, Yong-Fu Shao, Bing-Xiu Xiao, Jun-Ming Guo, Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, Zhejiang Province, China.
  • Jiang XM; Pei-Fei Li, Sheng-Can Chen, Tian Xia, Xiao-Ming Jiang, Yong-Fu Shao, Bing-Xiu Xiao, Jun-Ming Guo, Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, Zhejiang Province, China.
  • Shao YF; Pei-Fei Li, Sheng-Can Chen, Tian Xia, Xiao-Ming Jiang, Yong-Fu Shao, Bing-Xiu Xiao, Jun-Ming Guo, Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, Zhejiang Province, China.
  • Xiao BX; Pei-Fei Li, Sheng-Can Chen, Tian Xia, Xiao-Ming Jiang, Yong-Fu Shao, Bing-Xiu Xiao, Jun-Ming Guo, Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, Zhejiang Province, China.
  • Guo JM; Pei-Fei Li, Sheng-Can Chen, Tian Xia, Xiao-Ming Jiang, Yong-Fu Shao, Bing-Xiu Xiao, Jun-Ming Guo, Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, Zhejiang Province, China.
World J Gastroenterol ; 20(18): 5411-9, 2014 May 14.
Article en En | MEDLINE | ID: mdl-24833871
Non-coding RNAs (ncRNAs) play key roles in development, proliferation, differentiation and apoptosis. Altered ncRNA expression is associated with gastric cancer occurrence, invasion, and metastasis. Moreover, aberrant expression of microRNAs (miRNAs) is significantly related to gastric cancer tumor stage, size, differentiation and metastasis. MiRNAs interrupt cellular signaling pathways, inhibit the activity of tumor suppressor genes, and affect the cell cycle in gastric cancer cells. Some miRNAs, including miR-21, miR-106a and miR-421, could be potential markers for the diagnosis of gastric cancer. Long non-coding RNAs (lncRNAs), a new research hotspot among cancer-associated ncRNAs, play important roles in epigenetic, transcriptional and post-transcriptional regulation. Several gastric cancer-associated lncRNAs, such as CCAT1, GACAT1, H19, and SUMO1P3, have been explored. In addition, Piwi-interacting RNAs, another type of small ncRNA that is recognized by gastroenterologists, are involved in gastric carcinogenesis, and piR-651/823 represents an efficient diagnostic biomarker of gastric cancer that can be detected in the blood and gastric juice. Small interfering RNAs also function in post-transcriptional regulation in gastric cancer and might be useful in gastric cancer treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / ARN no Traducido Límite: Animals / Humans Idioma: En Revista: World J Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2014 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / ARN no Traducido Límite: Animals / Humans Idioma: En Revista: World J Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2014 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos