Your browser doesn't support javascript.
Efficacy and safety of valsartan/amlodipine single-pill combination in patients with essential hypertension (PEAK LOW).
Turk Kardiyol Dern Ars ; 42(4): 339-48, 2014 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-24899477
ABSTRACT

OBJECTIVES:

This study evaluated the efficacy as well as the safety and tolerability profile of low-dose valsartan/amlodipine (Val/Amlo) single-pill combination (SPC) (160/5 mg) in patients with essential hypertension in Turkey. STUDY

DESIGN:

Adult patients with essential hypertension [systolic blood pressure (SBP)>140 mmHg and/or diastolic blood pressure (DBP)>90 mmHg], who were on low dose Val/Amlo (160/5 mg) SPC before enrollment and gave informed consent, were accepted for this multi-centric observational study performed at 30 sites. The absolute changes in SBP and DBP from baseline were the primary efficacy outcomes. Safety assessments consisted of recording all adverse events.

RESULTS:

Of 381 patients enrolled, 327 completed the study; 39% were females. The mean age was 57.3±11.8 years. Median duration of hypertension was 38 months. Both SBP and DBP values showed reductions from 162.6±16.6 mmHg and 94.0±13.2 mmHg to 137.6±14.2 mmHg and 81.9±9.0 mmHg at 4th week and to 131.6±11.5 mmHg and 79.7±7.6 mmHg at 12th week, respectively. The control and response rates at the end of the study were 82.0% and 92.6%, respectively. Twelve patients (3.2%) experienced a total of 12 adverse events; there were no serious adverse events. The most common adverse event was edema (1.3%). Patient compliance was approximately 99%.

CONCLUSION:

Low-dose (160/5 mg) Val/Amlo SPC is efficacous and has a good tolerability and safety profile for the management of essential hypertension in Turkey.
Asunto(s)

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Tetrazoles / Valina / Amlodipino / Hipertensión / Antihipertensivos Tipo de estudio: Ensayo clínico controlado Límite: Anciano / Femenino / Humanos / Masculino / Media edad País/Región como asunto: Asia Idioma: Inglés Revista: Turk Kardiyol Dern Ars Asunto de la revista: Cardiología Año: 2014 Tipo del documento: Artículo País de afiliación: Turquía