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Lipidated peptidomimetics with improved antimicrobial activity.
Hu, Yaogang; Amin, Mohamad Nassir; Padhee, Shruti; Wang, Rongsheng E; Qiao, Qiao; Bai, Ge; Li, Yaqong; Mathew, Archana; Cao, Chuanhai; Cai, Jianfeng.
Afiliación
  • Hu Y; Department of Chemistry and College of Pharmacy, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
  • Amin MN; Department of Chemistry and College of Pharmacy, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
  • Padhee S; Department of Chemistry and College of Pharmacy, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
  • Wang RE; Department of Chemistry and College of Pharmacy, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
  • Qiao Q; Department of Chemistry and College of Pharmacy, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
  • Bai G; Department of Chemistry and College of Pharmacy, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
  • Li Y; Department of Chemistry and College of Pharmacy, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
  • Mathew A; Department of Chemistry and College of Pharmacy, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
  • Cao C; Department of Chemistry and College of Pharmacy, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
  • Cai J; Department of Chemistry and College of Pharmacy, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
ACS Med Chem Lett ; 3(8): 683-6, 2012 Aug 09.
Article en En | MEDLINE | ID: mdl-24900530
ABSTRACT
We report a series of lipidated α-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated α-AApeptides show broad-spectrum activity against a range of clinically related Gram-positive and Gram-negative bacteria as well as fungus. Their antimicrobial activity and selectivity are comparable or even superior to the clinical candidate pexiganan as well as previously reported linear α-AApeptides. The further development of lipidated α-AApeptides will lead to a new class of antibiotics to combat drug resistance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos