New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi.
ACS Med Chem Lett
; 4(6): 538-41, 2013 Jun 13.
Article
en En
| MEDLINE
| ID: mdl-24900706
ABSTRACT
The antiparasitic activity of azole and new 4-aminopyridine derivatives has been investigated. The imidazoles 1 and 3-5 showed a potent in vitro antichagasic activity with IC50 values in the low nanomolar concentration range. The (S)-1, (S)-3, and (S)-5 enantiomers showed (up to) a thousand-fold higher activity than the reference drug benznidazole and furthermore low cytotoxicity on rat myogenic L6 cells.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
ACS Med Chem Lett
Año:
2013
Tipo del documento:
Article
País de afiliación:
Italia