Efficacy of nebulised budesonide versus oral prednisolone in acute severe asthma.
Indian J Pediatr
; 82(4): 328-32, 2015 Apr.
Article
en En
| MEDLINE
| ID: mdl-24903131
ABSTRACT
OBJECTIVE:
To compare the efficacy of nebulised budesonide with that of oral prednisone in the treatment of acute severe asthma in children.METHODS:
Children aged 5-12 y with acute exacerbation of bronchial asthma were included. The study (budesonide) group received budesonide respirator solution (800 µg) at intervals of 20 min and a single dose of placebo tablets. The control (prednisolone) group received placebo solution at intervals of 20 min and a single dose of oral prednisolone (2 mg/kg). Both groups received three doses of nebulised salbutamol (0.15 mg/kg). Heart rate, respiratory rate, oxygen saturation, PEFR (Peak Expiratory Flow Rate) and fitness for discharge were assessed.RESULTS:
Both groups showed a progressive decrease in tachycardia with treatment, but it was significantly greater in study group (p = 0.0002). There was significant decrease in tachypnea and improvement in oxygen saturation in both groups, but the difference between the groups (p = 0.334 and p = 0.814 respectively) was not significant. There was significant improvement in PEFR values in budesonide group (p = 0.024). Both groups showed significant improvement in clinical severity scores at the end of 2 h (p < 0.0001). Budesonide group had significantly higher proportion of patients fit for discharge at 2 h (based on clinical severity scores) (p = 0.0278).CONCLUSIONS:
Nebulised budesonide significantly improves PEFR levels and fitness for discharge at 2 h when compared to oral prednisolone in children between 5 and 12 y with acute severe asthma.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estado Asmático
/
Prednisolona
/
Budesonida
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
Aspecto:
Patient_preference
Límite:
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Indian J Pediatr
Año:
2015
Tipo del documento:
Article
País de afiliación:
India