Porous silicon-cyclodextrin based polymer composites for drug delivery applications.
Carbohydr Polym
; 110: 238-52, 2014 Sep 22.
Article
en En
| MEDLINE
| ID: mdl-24906752
ABSTRACT
One of the main applications of porous silicon (PSi) in biomedicine is drug release, either as a single material or as a part of a composite. PSi composites are attractive candidates for drug delivery systems because they can display new chemical and physical characteristics, which are not exhibited by the individual constituents alone. Since cyclodextrin-based polymers have been proven efficient materials for drug delivery, in this work ß-cyclodextrin-citric acid in-situ polymerization was used to functionalize two kinds of PSi (nanoporous and macroporous). The synthesized composites were characterized by microscopy techniques (SEM and AFM), physicochemical methods (ATR-FTIR, XPS, water contact angle, TGA and TBO titration) and a preliminary biological assay was performed. Both systems were tested as drug delivery platforms with two different model drugs, namely, ciprofloxacin (an antibiotic) and prednisolone (an anti-inflammatory), in two different media pure water and PBS solution. Results show that both kinds of PSi/ß-cyclodextrin-citric acid polymer composites, nano- and macro-, provide enhanced release control for drug delivery applications than non-functionalized PSi samples.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Silicio
/
Portadores de Fármacos
/
Ácido Cítrico
/
Beta-Ciclodextrinas
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Carbohydr Polym
Año:
2014
Tipo del documento:
Article