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Targeting 4-1BB costimulation to the tumor stroma with bispecific aptamer conjugates enhances the therapeutic index of tumor immunotherapy.
Schrand, Brett; Berezhnoy, Alexey; Brenneman, Randall; Williams, Anthony; Levay, Agata; Kong, Ling-Yuan; Rao, Ganesh; Zhou, Shouhao; Heimberger, Amy B; Gilboa, Eli.
Afiliación
  • Schrand B; Department of Microbiology and Immunology, Dodson Interdisciplinary Immunotherapy Institute, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida.
  • Berezhnoy A; Department of Microbiology and Immunology, Dodson Interdisciplinary Immunotherapy Institute, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida.
  • Brenneman R; Department of Microbiology and Immunology, Dodson Interdisciplinary Immunotherapy Institute, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida.
  • Williams A; Department of Pathology, Miller School of Medicine, University of Miami, Miami, Florida.
  • Levay A; Department of Microbiology and Immunology, Dodson Interdisciplinary Immunotherapy Institute, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida.
  • Kong LY; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Rao G; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Zhou S; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Heimberger AB; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Gilboa E; Department of Microbiology and Immunology, Dodson Interdisciplinary Immunotherapy Institute, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida. egilboa@med.miami.edu.
Cancer Immunol Res ; 2(9): 867-77, 2014 Sep.
Article en En | MEDLINE | ID: mdl-24938283
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Activación de Linfocitos / Linfocitos T CD8-positivos / Aptámeros de Nucleótidos / Miembro 9 de la Superfamilia de Receptores de Factores de Necrosis Tumoral / Terapia Molecular Dirigida / Inmunoterapia / Neoplasias Experimentales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Cancer Immunol Res Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Activación de Linfocitos / Linfocitos T CD8-positivos / Aptámeros de Nucleótidos / Miembro 9 de la Superfamilia de Receptores de Factores de Necrosis Tumoral / Terapia Molecular Dirigida / Inmunoterapia / Neoplasias Experimentales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Cancer Immunol Res Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos