Effect of carbazochrome sodium sulfonate on refractory chronic prostatitis.
Int J Urol
; 21(11): 1162-6, 2014 Nov.
Article
en En
| MEDLINE
| ID: mdl-24964194
ABSTRACT
OBJECTIVES:
To study the effect of carbazochrome sodium sulfonate, an agent that reduces capillary permeability, on refractory chronic prostatitis.METHODS:
Patients with prostatitis refractory to at least 8 weeks of routine therapy and with urinalysis positive for microhematuria were considered for the present study. In addition to their prior therapy, the patients received carbazochrome at a dose of 30 mg three times a day. The severity of pain (score 0-10), daytime and night-time frequency, international prostate symptom score, global self-assessment, urine occult blood positivity, and adverse events were assessed after 4 and 8 weeks of treatment, and compared with baseline findings.RESULTS:
A total of 50 patients (mean age 68.6 ± 8.5 years) were evaluable. The pain score decreased significantly from 3.2 ± 2.1 at baseline to 1.7 ± 1.4 after 4 weeks of treatment and to 1.1 ± 1.8 after 8 weeks. Daytime and night-time frequency, storage symptoms, post-micturition symptoms, and urine occult blood positivity also significantly improved. More than 36% of the patients gave a global self-assessment rating of "improved" or "better" after both 4 and 8 weeks of treatment. Mild adverse events occurred in three patients; one had nausea and two developed drug rash.CONCLUSIONS:
Carbazochrome seems to effectively improve pain as well as storage and post-micturition symptoms in patients with refractory chronic prostatitis.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Prostatitis
/
Hemostáticos
/
Adrenocromo
Tipo de estudio:
Clinical_trials
Límite:
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Int J Urol
Asunto de la revista:
UROLOGIA
Año:
2014
Tipo del documento:
Article