Platelet vacuoles in a dog with severe nonregenerative anemia: evidence of platelet autophagy.
Vet Clin Pathol
; 43(3): 326-9, 2014 Sep.
Article
en En
| MEDLINE
| ID: mdl-24976524
ABSTRACT
A 13-year-old neutered male English Springer Spaniel was presented to The Ohio State University Veterinary Medical Center for evaluation of severe anemia. Upon blood smear review, approximately 50% of the platelets contained single to multiple variably sized clear vacuoles. Transmission electron microscopy of the platelets revealed hallmark features of autophagy, including membrane-lined vesicles and vacuoles containing membrane whorls and degrading organelles. While autophagy has been demonstrated in a wide range of eukaryotic cells for decades, reports of platelet autophagy are lacking. This case report illustrates atypical platelet vacuolation with electron microscopic features characteristic of autophagy.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Autofagia
/
Vacuolas
/
Plaquetas
/
Enfermedades de los Perros
/
Anemia
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Vet Clin Pathol
Asunto de la revista:
MEDICINA VETERINARIA
/
PATOLOGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos