Rho GTPases: masters of cell migration.
Small GTPases
; 5: e29710, 2014.
Article
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| MEDLINE
| ID: mdl-24978113
ABSTRACT
Since their discovery in the late eighties, the role of Rho GTPases in the regulation of cell migration has been extensively studied and has mainly focused on the hallmark family members Rho, Rac, and Cdc42. Recent technological advances in cell biology, such as Rho-family GTPase activity biosensors, studies in 3D, and unbiased RNAi-based screens, have revealed an increasingly complex role for Rho GTPases during cell migration, with many inter-connected functions and a strong dependency on the physical and chemical properties of the surrounding environment. This review aims to give an overview of recent studies on the role of Rho-family GTPase members in the modulation of cell migration in different environments, and discuss future directions.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas de Unión al GTP rho
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Small GTPases
Año:
2014
Tipo del documento:
Article
País de afiliación:
Reino Unido