Lung recruitment manoeuvres do not cause haemodynamic instability or oxidative stress but improve oxygenation and lung mechanics in a newborn animal model: an observational study.
Eur J Anaesthesiol
; 31(9): 457-65, 2014 Sep.
Article
en En
| MEDLINE
| ID: mdl-24979585
ABSTRACT
BACKGROUND:
Lung recruitment manoeuvres in neonates during anaesthesia are not performed routinely due to concerns about causing barotrauma, haemodynamic instability and oxidative stress.OBJECTIVE:
To assess the influence of recruitment manoeuvres and positive end-expiratory pressure (PEEP) on haemodynamics, oxidative stress, oxygenation and lung mechanics.DESIGN:
A prospective experimental study.SETTING:
Experimental Unit, La Paz University Hospital, Madrid, Spain. ANIMALS Eight newborn piglets (<48âh) with healthy lungs under general anaesthesia.INTERVENTIONS:
The recruitment manoeuvres in pressure-controlled ventilation (PCV) were performed along with a constant driving pressure of 15âcmH2O. After the recruitment manoeuvres, PEEP was reduced in a stepwise fashion to find the maximal dynamic compliance step (maxCDyn-PEEP). Blood oxidative stress biomarkers (lipid peroxidation products, protein carbonyls, total glutathione, oxidised glutathione, reduced glutathione and activity of glutathione peroxidase) were analysed. MAIN OUTCOMEMEASURES:
Haemodynamic parameters, arterial partial pressure of oxygen (paO2), tidal volume (Vt), dynamic compliance (Cdyn) and oxidative stress biomarkers were measured.RESULTS:
The recruitment manoeuvres did not induce barotrauma. Haemodynamic instability was not detected either in the maximum pressure step (overdistension step 5) or during the entire process. No substantial differences were observed in blood oxidative stress parameters analysed as compared with their baseline values (with 0 PEEP) or the values obtained 180âmin after the onset of the recruitment manoeuvres (optimal PEEP). Significant maximal values were achieved in step 14 with an increase in paO2 (32.43â±â8.48 vs. 40.39â±â15.66âkPa; Pâ=â0.037), Vt (47.75â±â13.59 vs. 73.87â±â13.56âml; Pâ=â0.006) and Cdyn (2.50â±â0.64 vs. 4.75â±â0.88âml cmH2O; Pâ<â0.001). Maximal dynamic compliance step (maxCdyn-PEEP) was 2âcmH2O.CONCLUSION:
Recruitment manoeuvres in PCV with a constant driving pressure are a well tolerated open-lung strategy in a healthy-lung neonatal animal model under general anaesthesia. The recruitment manoeuvres improve oxygenation parameters and lung mechanics and do not cause barotrauma, haemodynamic instability or oxidative stress.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxígeno
/
Respiración con Presión Positiva
/
Estrés Oxidativo
/
Pulmón
Tipo de estudio:
Etiology_studies
/
Observational_studies
Límite:
Animals
País/Región como asunto:
Europa
Idioma:
En
Revista:
Eur J Anaesthesiol
Asunto de la revista:
ANESTESIOLOGIA
Año:
2014
Tipo del documento:
Article