Spontaneous glomerular mesangial lesions in common marmoset monkeys (Callithrix jacchus): a benign non-progressive glomerulopathy.
J Med Primatol
; 43(6): 477-87, 2014 Dec.
Article
en En
| MEDLINE
| ID: mdl-24980800
ABSTRACT
BACKGROUND:
Common marmosets are known to develop an IgM glomerulopathy, which has been linked with 'wasting marmoset' syndrome. This study investigated renal pathology in a colony of marmosets, with and without weight loss.METHODS:
Renal histology, immunofluorescence, and electron microscopy were performed on marmosets euthanized for research or for weight loss. Serum and urine biochemistry were measured during life and at euthanasia.RESULTS:
Histology from 25 adult marmosets (19 research and 6 weight loss) showed mesangial expansion in the majority of glomeruli. Mesangial changes correlated with electron-dense deposits and IgM deposition by immunofluorescence; negligible other pathology was seen. Glomerular basement membrane thickness appeared increased compared to reported human measurements. Low-grade proteinuria was present in all animals, but did not progress. Renal function was normal in all animals.CONCLUSIONS:
Marmosets develop a glomerulopathy characterized by mesangial expansion, IgM deposition, and proteinuria. This is a benign occurrence and not specifically associated with weight loss.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Callithrix
/
Mesangio Glomerular
/
Enfermedades de los Monos
/
Nefrosis
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
J Med Primatol
Año:
2014
Tipo del documento:
Article
País de afiliación:
Australia