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Structure-based optimization and biological evaluation of trisubstituted pyrazole as a core structure of potent ROS1 kinase inhibitors.
Park, Byung Sun; Al-Sanea, Mohammad M; Abdelazem, Ahmed Z; Park, Hye Mi; Roh, Eun Joo; Park, Hyun-Mee; Yoo, Kyung Ho; Sim, Taebo; Tae, Jin Sung; Lee, So Ha.
Afiliación
  • Park BS; Department of Chemistry, Yonsei University, 134, Sinchon-dong, Seodaemun-gu, Seoul 120-749, Republic of Korea.
  • Al-Sanea MM; Chemical Kinomics Research Center, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea; Department of Biological Chemistry, Korea University of Science and Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon 305-333, Republic of Korea.
  • Abdelazem AZ; Chemical Kinomics Research Center, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea; Department of Biological Chemistry, Korea University of Science and Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon 305-333, Republic of Korea.
  • Park HM; Chemical Kinomics Research Center, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.
  • Roh EJ; Chemical Kinomics Research Center, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea. Electronic address: r8636@kist.re.kr.
  • Park HM; Advanced Analysis Center, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.
  • Yoo KH; Chemical Kinomics Research Center, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.
  • Sim T; Chemical Kinomics Research Center, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.
  • Tae JS; Department of Chemistry, Yonsei University, 134, Sinchon-dong, Seodaemun-gu, Seoul 120-749, Republic of Korea.
  • Lee SH; Chemical Kinomics Research Center, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea. Electronic address: LSH6211@kist.re.kr.
Bioorg Med Chem ; 22(15): 3871-8, 2014 Aug 01.
Article en En | MEDLINE | ID: mdl-24997577
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Proteínas Tirosina Quinasas / Proteínas Proto-Oncogénicas / Inhibidores de Proteínas Quinasas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Proteínas Tirosina Quinasas / Proteínas Proto-Oncogénicas / Inhibidores de Proteínas Quinasas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido