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The effect of vitamin C intake on the risk of hyperuricemia and serum uric acid level in Korean Multi-Rural Communities Cohort.
Bae, Jisuk; Shin, Dong Hoon; Chun, Byung-Yeol; Choi, Bo Youl; Kim, Mi Kyung; Shin, Min-Ho; Lee, Young-Hoon; Park, Pil Sook; Kim, Seong-Kyu.
Afiliación
  • Bae J; Department of Preventive Medicine, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea.
  • Shin DH; Department of Preventive Medicine, School of Medicine Keimyung University, Daegu, Republic of Korea.
  • Chun BY; Department of Preventive Medicine, School of Medicine, Health Promotion Research Center, Kyungpook National University, Daegu, Republic of Korea.
  • Choi BY; Department of Preventive Medicine, Hanyang University, College of Medicine, Seoul, Republic of Korea.
  • Kim MK; Department of Preventive Medicine, Hanyang University, College of Medicine, Seoul, Republic of Korea.
  • Shin MH; Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Lee YH; Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University College of Medicine, Iksan, Jeonlabuk-do, Republic of Korea.
  • Park PS; Department of Food and Nutrition, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, Republic of Korea. Electronic address: pspark@knu.ac.kr.
  • Kim SK; Division of Rheumatology, Department of Internal Medicine, Arthritis and Autoimmunity Research Center, Catholic University of Daegu School of Medicine, 3056-6 Daemyung 4-Dong, Namgu, Daegu 705-718, Republic of Korea. Electronic address: kimsk714@cu.ac.kr.
Joint Bone Spine ; 81(6): 513-9, 2014 Dec.
Article en En | MEDLINE | ID: mdl-24998789
OBJECTIVE: The aim of this study was to determine the association between vitamin C intake and risk of hyperuricemia or serum uric acid levels in male and female subjects in the Korean Multi-Rural Communities Prospective Cohort. METHODS: This cross-sectional analysis was conducted in 9400 subjects enrolled in the Korean Multi-Rural Communities Cohort Study. The risk of hyperuricemia was assessed in five quintiles (Q1 to Q5) according to dietary and total vitamin C intake using multivariate-adjusted logistic regression models. Relationships between serum uric acid levels and vitamin C intake were evaluated using linear regression analysis after adjustment for covariates. Information about dietary components was collected using validated food frequency questionnaires. RESULTS: Dietary vitamin C intake, but not total vitamin C intake, was significantly different between hyperuricemic and non-hyperuricemic subjects in males (P=0.01) and females (P=0.02). The risk of hyperuricemia decreased with increased dietary vitamin C intake in male and female subjects after multivariate adjustment (P for trend=0.002 in males and P for trend=0.02 in females). An effect of total vitamin C intake on hyperuricemia risk was identified in females (P for trend=0.04), but not males (P for trend=0.06). Serum uric acid level was linearly associated with total vitamin C intake in females (ß=-0.0001, P=0.01), but not with dietary vitamin C intake in either gender. CONCLUSION: This study showed that vitamin C intake might be in part responsible for hyperuricemia or serum uric acid level in the Korean Multi-Rural Communities Cohort.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Ascórbico / Ácido Úrico / Hiperuricemia Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Joint Bone Spine Asunto de la revista: REUMATOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Francia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Ascórbico / Ácido Úrico / Hiperuricemia Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Joint Bone Spine Asunto de la revista: REUMATOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Francia