Characterization of a brain permeant fluorescent molecule and visualization of Aß parenchymal plaques, using real-time multiphoton imaging in transgenic mice.
Org Lett
; 16(14): 3640-3, 2014 Jul 18.
Article
en En
| MEDLINE
| ID: mdl-25003699
ABSTRACT
Emerging paradigms mandate discovery of imaging agents for diagnosing Alzheimer's disease (AD) prior to appearance of clinical symptoms. To accomplish this objective, a novel heterocyclic molecule (4) was synthesized and validated as Aß targeted probe. The agent shows labeling of numerous diffuse Aß plaques in confirmed AD human brain tissues and traverses the blood-brain barrier to enable labeling of parenchymal Aß plaques in live mice (APP(±)/PS1(±)) brains.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piridinas
/
Encéfalo
/
Placa Amiloide
/
Benzotiazoles
/
Enfermedad de Alzheimer
/
Colorantes Fluorescentes
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos