Emerging science of the human microbiome.
Gut Microbes
; 5(4): 446-57, 2014 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-25013912
ABSTRACT
The human gastrointestinal tract hosts a large number of microbial cells which exceed their mammalian counterparts by approximately 3-fold. The genes expressed by these microorganisms constitute the gut microbiome and may participate in diverse functions that are essential to the host, including digestion, regulation of energy metabolism, and modulation of inflammation and immunity. The gut microbiome can be modulated by dietary changes, antibiotic use, or disease. Different ailments have distinct associated microbiomes in which certain species or genes are present in different relative quantities. Thus, identifying specific disease-associated signatures in the microbiome as well as the factors that alter microbial populations and gene expression will lead to the development of new products such as prebiotics, probiotics, antimicrobials, live biotherapeutic products, or more traditional drugs to treat these disorders. Gained knowledge on the microbiome may result in molecular lab tests that may serve as personalized tools to guide the use of the aforementioned products and monitor interventional progress.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Salud
/
Enfermedades Transmisibles
/
Interacciones Huésped-Patógeno
/
Metagenómica
/
Microbiota
/
Microbiología
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Gut Microbes
Año:
2014
Tipo del documento:
Article