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The genetic architecture of pediatric cognitive abilities in the Philadelphia Neurodevelopmental Cohort.
Robinson, E B; Kirby, A; Ruparel, K; Yang, J; McGrath, L; Anttila, V; Neale, B M; Merikangas, K; Lehner, T; Sleiman, P M A; Daly, M J; Gur, R; Gur, R; Hakonarson, H.
Afiliación
  • Robinson EB; 1] Analytic and Translational Genetics Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA [2] Stanley Center for Psychiatric Research and Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Kirby A; 1] Analytic and Translational Genetics Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA [2] Stanley Center for Psychiatric Research and Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Ruparel K; Department of Psychiatry, Perelman of School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Yang J; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
  • McGrath L; Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
  • Anttila V; 1] Analytic and Translational Genetics Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA [2] Stanley Center for Psychiatric Research and Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA [3] Institut
  • Neale BM; 1] Analytic and Translational Genetics Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA [2] Stanley Center for Psychiatric Research and Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Merikangas K; Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
  • Lehner T; Office of Genomics Research Coordination, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
  • Sleiman PM; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Daly MJ; 1] Analytic and Translational Genetics Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA [2] Stanley Center for Psychiatric Research and Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Gur R; Department of Psychiatry, Perelman of School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Gur R; Department of Psychiatry, Perelman of School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Hakonarson H; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Mol Psychiatry ; 20(4): 454-8, 2015 Apr.
Article en En | MEDLINE | ID: mdl-25023143
ABSTRACT
The objective of this analysis was to examine the genetic architecture of diverse cognitive abilities in children and adolescents, including the magnitude of common genetic effects and patterns of shared and unique genetic influences. Subjects included 3689 members of the Philadelphia Neurodevelopmental Cohort, a general population sample comprising those aged 8-21 years who completed an extensive battery of cognitive tests. We used genome-wide complex trait analysis to estimate the SNP-based heritability of each domain, as well as the genetic correlation between all domains that showed significant genetic influence. Several of the individual domains suggested strong influence of common genetic variants (for example, reading ability, h(2)g=0.43, P=4e-06; emotion identification, h(2)g=0.36, P=1e-05; verbal memory, h(2)g=0.24, P=0.005). The genetic correlations highlighted trait domains that are candidates for joint interrogation in future genetic studies (for example, language reasoning and spatial reasoning, r(g)=0.72, P=0.007). These results can be used to structure future genetic and neuropsychiatric investigations of diverse cognitive abilities.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Discapacidades del Desarrollo / Trastornos del Conocimiento / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans / Male País/Región como asunto: America do norte Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Discapacidades del Desarrollo / Trastornos del Conocimiento / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans / Male País/Región como asunto: America do norte Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos