[Comparative study of the toxicity and antiarrhythmic activity of some organic derivatives of dimethylacetamide].
Eksp Klin Farmakol
; 77(5): 20-2, 2014.
Article
en Ru
| MEDLINE
| ID: mdl-25033567
ABSTRACT
A comparative study of the acute toxicity and antiarrhythmic activity of new domestic derivatives of dimethylacetamide showed that the introduction of amino and carboxylic acid residues into the structure of compounds is accompanied by reduction of the toxic properties of new substances on the average 2.73 times (p = 0.002) upon intraperitoneal introduction to animals. It has been established that the derivatives are able to prevent the formation of aconitine induced arrhythmias and eliminate the arrhythmia that occurs on the second day of myocardial infarction in dogs. Original derivatives of dimethylacetamide exhibit antiarrhythmic properties and their activity increases in proportion to the acute toxicity (r = 0.83, p = 0.0043).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Arritmias Cardíacas
/
Crioprotectores
/
Acetamidas
/
Antiarrítmicos
/
Infarto del Miocardio
Límite:
Animals
Idioma:
Ru
Revista:
Eksp Klin Farmakol
Asunto de la revista:
FARMACOLOGIA
Año:
2014
Tipo del documento:
Article