Predictive factors for kidney damage in febrile urinary tract infection. Usefulness of procalcitonin.
Nefrologia
; 34(4): 451-7, 2014.
Article
en En, Es
| MEDLINE
| ID: mdl-25036058
ABSTRACT
OBJECTIVE:
To establish the utility of procalcitonin (PCT) and other clinical and analytical parameters as markers of acute and permanent renal damage in children after a first febrile urinary tract infection (UTI).METHODS:
Retrospective multicentre study. Statistical study descriptive, receiver operating characteristic (ROC) curves and multiple logistic regression.RESULTS:
219 patients, aged between 1 week and 14 years (68% under 1 year). The mean PCT values were significantly higher in patients with acute pyelonephritis with respect to normal acute DMSA (4.8 vs 1.44; p=0.0001), without achieving that signification for late affected DMSA (6.5 vs 5.05; p=0.6). The area under the ROC curve for PCT was 0.64 (CI 95% 0.55-0.72) for acute renal damage, and 0.62 (CI 95% 0.44-0.80) for permanent damage, with optimum statistical cut-off values of 0.85 and 1.17ng/ml. Multivariate analysis for acute renal damage only found correlation with PCT (Odds Ratio [OR] 1.2 (CI 95% 1.06-1.4, p=0.005), and hours of fever (OR for less than 6 hours of fever 0.4 (CI 95% 0.2-1.02, p=0.05). In patients with renal scarring, PCT showed an OR 1.0 (CI 95% 0.9-1.1, p=0.6).CONCLUSIONS:
PCT and the duration of fever were the only parameters statistically associated with early renal damage. PCT and renal scarring did not reach statistical significance.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Precursores de Proteínas
/
Infecciones Urinarias
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Calcitonina
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Enfermedades Renales
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
/
Es
Revista:
Nefrologia
Año:
2014
Tipo del documento:
Article
Pais de publicación:
ES
/
ESPANHA
/
ESPAÑA
/
SPAIN