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ß-l-1-[5-(E-2-bromovinyl)-2-(hydroxymethyl)-1,3-(dioxolan-4-yl)] uracil (l-BHDU) prevents varicella-zoster virus replication in a SCID-Hu mouse model and does not interfere with 5-fluorouracil catabolism.
De, Chandrav; Liu, Dongmei; Zheng, Bo; Singh, Uma S; Chavre, Satish; White, Catherine; Arnold, Robert D; Hagen, Fred K; Chu, Chung K; Moffat, Jennifer F.
Afiliación
  • De C; Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, NY, USA. Electronic address: dec@upstate.edu.
  • Liu D; Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, NY, USA. Electronic address: liud@upstate.edu.
  • Zheng B; Department of Pharmaceutics, College of Pharmacy, State University of New York at Buffalo, Buffalo, NY, USA. Electronic address: bozheng@buffalo.edu.
  • Singh US; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA, USA. Electronic address: ussingh@rx.uga.edu.
  • Chavre S; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA, USA. Electronic address: schavre@rx.uga.edu.
  • White C; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA, USA. Electronic address: cwhite@rx.uga.edu.
  • Arnold RD; Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, USA. Electronic address: rda0007@auburn.edu.
  • Hagen FK; Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA. Electronic address: fred_hagen@urmc.rochester.edu.
  • Chu CK; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA, USA. Electronic address: dchu@mail.rx.uga.edu.
  • Moffat JF; Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, NY, USA. Electronic address: moffatj@upstate.edu.
Antiviral Res ; 110: 10-9, 2014 Oct.
Article en En | MEDLINE | ID: mdl-25051026
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Uracilo / Replicación Viral / Herpesvirus Humano 3 / Dioxolanos / Fluorouracilo / Nucleósidos Límite: Animals / Humans Idioma: En Revista: Antiviral Res Año: 2014 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Uracilo / Replicación Viral / Herpesvirus Humano 3 / Dioxolanos / Fluorouracilo / Nucleósidos Límite: Animals / Humans Idioma: En Revista: Antiviral Res Año: 2014 Tipo del documento: Article Pais de publicación: Países Bajos