DRESS syndrome due to antibiotic therapy of osteoarticular infections in children: two case reports.
Rev Esp Cir Ortop Traumatol
; 59(5): 360-4, 2015.
Article
en En, Es
| MEDLINE
| ID: mdl-25052739
ABSTRACT
Osteoarticular infection in children frequently occurs before 10 years of age. Surgical drainage is sometimes required, whereas acute osteomyelitis can be treated with antibiotic therapy alone. The duration of antibiotic therapy varies, 2 weeks is sufficient for septic arthritis, whereas 6 weeks is often required for complicated cases. Some of these antibiotic drugs present direct complications with low clinical impact in certain individuals. Hypersensitivity to these drugs causes different reactions in children. DRESS syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms) is a severe and potentially life-threatening drug reaction. It is characterised by high fever, malaise, lymphadenopathy and skin rash. From a clinical perspective, these symptoms can lead to an exacerbation of the initial infectious process for which treatment was commenced. The liver is the organ most often affected in DRESS syndrome associated with haematological changes, potentially similar to sepsis. We present two cases of children with osteoarticular infections who developed DRESS syndrome after antibiotic therapy. Both patients made a complete recovery after cessation of the antibiotic drugs used.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Osteomielitis
/
Artritis Infecciosa
/
Cefotaxima
/
Cloxacilina
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Síndrome de Hipersensibilidad a Medicamentos
/
Articulación de la Rodilla
/
Antibacterianos
Tipo de estudio:
Diagnostic_studies
Límite:
Child
/
Humans
/
Male
Idioma:
En
/
Es
Revista:
Rev Esp Cir Ortop Traumatol
Año:
2015
Tipo del documento:
Article