[Determination of the plasma global antioxidant capacity: a critical review]. / Mesure de la capacité antioxydante globale du plasma : une revue critique.
Ann Biol Clin (Paris)
; 72(4): 413-21, 2014.
Article
en Fr
| MEDLINE
| ID: mdl-25119799
ABSTRACT
With respect to prevention of cardiovascular diseases and cancers, the healthcare professionals are more and more interested in the blood determination of antioxidants (vitamins C and E, carotenoids, glutathione, ubiquinone, antioxidant enzymes). The major problem of these analysis is their elevated cost. At the request of the healthcare professionals, the laboratories of clinical biology suggest the measurement of the plasma global antioxidant capacity (GAC) as a replacement of the individual determination of all these antioxidants. The present review shows that such a test presents a large number of gaps, the major one being that it essentially reflects the plasma concentration of uric acid and proteins. On basis of nine arguments, we show that the measurement of the plasma GAC cannot be considered as an in vivo marker of oxidative stress nor lead to the prescription antioxidant complement.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plasma
/
Antioxidantes
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
Fr
Revista:
Ann Biol Clin (Paris)
Año:
2014
Tipo del documento:
Article
País de afiliación:
Bélgica