Antibiotic susceptibility of Estrella lausannensis, a potential emerging pathogen.
Microbes Infect
; 16(9): 746-54, 2014 Sep.
Article
en En
| MEDLINE
| ID: mdl-25150688
ABSTRACT
Estrella lausannensis is a new Chlamydia-related bacterium, belonging to the Criblamydiaceae family. As suggested by its species name, this bacterium harbors a peculiar star shape. E. lausannensis is able to infect a wide range of amoebal, fish and mammalian cell lines. Moreover, seroprevalence of 2.9% was reported in children and in women with tubal pathology, showing that humans are commonly exposed to this recently discovered strict intracellular bacteria considered as a potential pathogen. Antibiotic susceptibility was determined using two approaches qPCR and cellular mortality assay. Antibiotics classically used against intracellular bacteria were tested, including ß-lactams, fluoroquinolones, cyclines and macrolides. We showed that E. lausannensis is resistant to ß-lactams and fluoroquinolones, and sensitive to cyclines. Interestingly, E. lausannensis is slightly resistant to azithromycin with a MIC of 2 µg/ml, which is 10 fold higher compared to Waddlia chondrophila and Parachlamydia acanthamoebae MIC's. A single A2059C mutation in 23S rRNA gene could be responsible for this unexpected resistance.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Chlamydiales
/
Antibacterianos
Límite:
Animals
/
Child, preschool
/
Female
/
Humans
Idioma:
En
Revista:
Microbes Infect
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
MICROBIOLOGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Suiza