Transforming growth factor-ß1 gene polymorphism in mycosis fungoides.
Clin Exp Dermatol
; 39(7): 806-9, 2014 Oct.
Article
en En
| MEDLINE
| ID: mdl-25156636
ABSTRACT
BACKGROUND:
Dysregulation in transforming growth factor (TGF)-ß1 signalling pathways has been linked to cancer.AIM:
To study the association between single nucleotide polymorphisms (SNPs) of the TGF-ß1 gene and mycosis fungoides (MF).METHODS:
Using restriction fragment length polymorphism analysis, SNPs in the TGF-ß1 gene were studied in 55 patients with MF of different stages and in 100 apparently healthy controls.RESULTS:
A significant difference was found between patients and controls in distribution of the different TGF-ß1 genotypes, with mutant forms (T/C, T/T) encountered significantly more often in patients with MF (P < 0.001). The heterozygous genotype (T/C) was significantly associated with patch stage MF, whereas the homozygous genotype (T/T) was significantly associated with tumour stage (stage IIb) MF (P = 0.001), although this study included only a small number of these patients.CONCLUSIONS:
Mutant TGF-ß1 genotypes are significantly associated with MF in Egyptian patients, with the homozygous genotype (T/T) having a stronger association with tumour stage (stage IIb).
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
/
Micosis Fungoide
/
Predisposición Genética a la Enfermedad
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Polimorfismo de Nucleótido Simple
/
Factor de Crecimiento Transformador beta1
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Africa
Idioma:
En
Revista:
Clin Exp Dermatol
Año:
2014
Tipo del documento:
Article
País de afiliación:
Egipto