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Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.
Sanches, Mario; Duffy, Nicole M; Talukdar, Manisha; Thevakumaran, Nero; Chiovitti, David; Canny, Marella D; Lee, Kenneth; Kurinov, Igor; Uehling, David; Al-awar, Rima; Poda, Gennadiy; Prakesch, Michael; Wilson, Brian; Tam, Victor; Schweitzer, Colleen; Toro, Andras; Lucas, Julie L; Vuga, Danka; Lehmann, Lynn; Durocher, Daniel; Zeng, Qingping; Patterson, John B; Sicheri, Frank.
Afiliación
  • Sanches M; 1] Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5 [2].
  • Duffy NM; 1] Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5 [2].
  • Talukdar M; 1] Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5 [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8 [3].
  • Thevakumaran N; 1] Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5 [2] Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
  • Chiovitti D; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.
  • Canny MD; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.
  • Lee K; 1] Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5 [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
  • Kurinov I; NE-CAT APS, Building 436E, Argonne National Lab, 9700 S.Cass Avenue, Argonne, Illinois 60439, USA.
  • Uehling D; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada M5G 0A3.
  • Al-awar R; 1] Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada M5G 0A3 [2] Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
  • Poda G; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada M5G 0A3.
  • Prakesch M; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada M5G 0A3.
  • Wilson B; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada M5G 0A3.
  • Tam V; MannKind Corporation, 28903 North Avenue Paine, Valencia, California 91355, USA.
  • Schweitzer C; MannKind Corporation, 28903 North Avenue Paine, Valencia, California 91355, USA.
  • Toro A; MannKind Corporation, 28903 North Avenue Paine, Valencia, California 91355, USA.
  • Lucas JL; MannKind Corporation, 28903 North Avenue Paine, Valencia, California 91355, USA.
  • Vuga D; MannKind Corporation, 28903 North Avenue Paine, Valencia, California 91355, USA.
  • Lehmann L; NanoTemper Technologies, Inc., 395 Oyster Point Boulevard, Suite 135, South San Francisco, California 94080, USA.
  • Durocher D; 1] Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5 [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
  • Zeng Q; MannKind Corporation, 28903 North Avenue Paine, Valencia, California 91355, USA.
  • Patterson JB; MannKind Corporation, 28903 North Avenue Paine, Valencia, California 91355, USA.
  • Sicheri F; 1] Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5 [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8 [3] Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
Nat Commun ; 5: 4202, 2014 Aug 28.
Article en En | MEDLINE | ID: mdl-25164867
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Relación Estructura-Actividad / Proteínas Serina-Treonina Quinasas / Inhibidores Enzimáticos / Proteínas de la Membrana Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Relación Estructura-Actividad / Proteínas Serina-Treonina Quinasas / Inhibidores Enzimáticos / Proteínas de la Membrana Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido