Disruption of lateral olivocochlear neurons with a dopaminergic neurotoxin depresses spontaneous auditory nerve activity.
Neurosci Lett
; 582: 54-8, 2014 Oct 17.
Article
en En
| MEDLINE
| ID: mdl-25175420
ABSTRACT
Neurons of the lateral olivocochlear (LOC) system project from the auditory brainstem to the cochlea, where they synapse on radial dendrites of auditory nerve fibers. Selective LOC disruption depresses sound-evoked auditory nerve activity in the guinea pig, but enhances it in the mouse. Here, LOC disruption depressed spontaneous auditory nerve activity in the guinea pig. Recordings from single auditory nerve fibers revealed a significantly reduced proportion of fibers with the highest spontaneous firing rates (SRs) and an increased proportion of neurons with lower SRs. Ensemble activity, estimated using round window noise, also decreased after LOC disruption. Decreased spontaneous activity after LOC disruption may be a consequence of reduced tonic release of excitatory transmitters from the LOC terminals in guinea pigs.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
1-Metil-4-fenil-1,2,3,6-Tetrahidropiridina
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Cóclea
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Nervio Coclear
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Neuronas Dopaminérgicas
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Complejo Olivar Superior
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2014
Tipo del documento:
Article