A new efficient route to 7-aryl-6-fluoro-8-nitroquinolones as potent antibacterial agents.
Eur J Med Chem
; 86: 364-7, 2014 Oct 30.
Article
en En
| MEDLINE
| ID: mdl-25180924
ABSTRACT
A series of 7-aryl-6-fluoro-8-nitroquinolones (6a-e) were synthesized through a novel, simple and clean synthetic procedure, through a Suzuki-Miyaura reaction. The target compounds were evaluated in vitro for their antimicrobial properties against bacterial and fungal strains. All of them showed antibacterial activity higher than the activity of ciprofloxacin, both towards Gram positive Bacillus subtilis and Staphylococcus aureus, and Gram negative Haemophilus influenzae strains. Compound 6d, containing the trisubstituted 7-aryl moiety, emerged as the most active quinolone derivative with MIC values ranging from 0.00007 µg/mL to 0.015 µg/mL.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Staphylococcus aureus
/
Bacillus subtilis
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Haemophilus influenzae
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Antibacterianos
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Nitroquinolinas
Idioma:
En
Revista:
Eur J Med Chem
Año:
2014
Tipo del documento:
Article
País de afiliación:
Jordania