[Effect of zige lyophilized powder for injection in improving acute cerebral microcirculation disturbance in rats].
Zhongguo Zhong Yao Za Zhi
; 39(4): 733-7, 2014 Feb.
Article
en Zh
| MEDLINE
| ID: mdl-25204156
ABSTRACT
OBJECTIVE:
To investigate the effect of Zige lyophilized powder for injection in improving the acute cerebral microcirculation disturbance in rats.METHOD:
Window craniotomy was performed for rats after the drug administration for 14 days. The experimental microcirculation disturbance model was duplicated with high molecule dextran. After the drug administration, the micro-vein diameters of cerebral pla mater of various groups were observed and recorded under the biological microscope. The blood flow volume was monitored by laser Doppler flow-meter. HCT was measured by the electric resistance method. The hemorheological indexes were detected by the auto-hemorheological instrument.RESULT:
Zige lyophilized powder for injection (16.40, 32.70, 65.40 mg x kg(-1)) could significantly expand the micro-vein diameter of cerebral pla mater, improve the downward trend of the blood flow volume, and reduce the various hemorheological indexes.CONCLUSION:
Zige lyophilized powder for injection shows the effect in improving the cerebral microcirculation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Medicamentos Herbarios Chinos
/
Isquemia Encefálica
/
Circulación Cerebrovascular
Límite:
Animals
/
Humans
/
Male
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Asunto de la revista:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Año:
2014
Tipo del documento:
Article