Thiourea-catalyzed enantioselective addition of indoles to pyrones: alkaloid cores with quaternary carbons.
J Am Chem Soc
; 136(39): 13614-7, 2014 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-25213353
ABSTRACT
We report the development of a catalytic method for the enantioselective addition of indoles to pyrone-derived electrophiles. Arylpyrrolidino-derived thioureas catalyze the addition with high stereoselectivity in the presence of catalytic quantities of an achiral Brønsted acid. The indole-pyrone adducts feature a quaternary stereocenter and represent an unusual class of indolines bearing structural resemblance to the hybrid natural product pleiocarpamine.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pironas
/
Tiourea
/
Alcaloides
/
Indoles
Idioma:
En
Revista:
J Am Chem Soc
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos